Imagine each game as a slightly different continuity (or all as parts of one BIG game, with different origin stories) taking place at the same time. So the new Wolf Hall PC arrives instead of the existing Horse Hall PC.
Virginia and Ellen will not have a third roommate, it'll be just the two of them.
If you check the sequel teaser thread you'll see that some yaoi is already promised.
Female protagonist, in the hall for adventurous girls.